Palladium‐Mediated C γ −H Functionalization of Alicyclic Amines

This paper describes a new method for the transannular functionalization of γ-C−H bonds in alicyclic amines to install C(sp3)−halogen, oxygen, nitrogen, boron, and sulfur bonds. The key challenge this transformation is controlling relative rate Cγ−H versus Cα−H functionalization. We demonstrate that selectivity can be achieved by pre-complexation substrate with Pd prior addition oxidant. approach enables use diverse oxidants ultimately various heteroatom functional groups at γ-position high site- diastereoselectivity.